Prokineticin-izing Doxorubicin-Damaged Hearts

De-maxim-izing Quality

Hyperthermia can differentially modulate the repair of doxorubicin-damaged DNA in normal and cancer cells.

Hyperthermia can modulate the action of many anticancer drugs, and DNA repair processes are temperature-dependent, but the character of this dependence in cancer and normal cells is largely unknown. This subject seems to be worth studying, because hyperthermia can assist cancer therapy. A 1-h incubation at 37 degrees C of normal human peripheral blood lymphocytes and human myelogenous leukemia ...

Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.

Prokineticins 1 and 2 (PK1 and PK2) have been recently identified from humans and other mammals and play multiple functional roles. PK proteins are ligands for two G protein-coupled receptors, PK receptor 1 (PKR1) and PK receptor 2 (PKR2). Here, we report the molecular cloning and pharmacological characterization of an alternatively spliced product of the PK2 gene encoding 21 additional amino a...

Playing Peter Pan Conceptua izing " Bois " in Contemporary Queer Theory

As a queer and gender-queer individual, my relationships to both lesbian as an identity and to Toronto's lesbian communities have been marked by a strangely productive ambiguity. While "coming out" as a lesbian was and continues to be empowering, I have become increasingly aware of my own emotional and intellectual tensions with respect to the signifier, "lesbian," as it purports to simultaneou...

Ylvi - Multimedia-izing the Semantic Wiki

Semantic and semi-structured wiki implementations, which extend traditional, purely string-based wikis by adding machine-processable metadata, suffer from a lack of support for media management. Currently, it is difficult to maintain semantically rich metadata for both wiki pages and associated media assets; media management functionalities are cumbersome or missing. With Ylvi, a semantic wiki ...